Def6 is required for convergent extension movements during zebrafish gastrulation downstream of Wnt5b signaling.
During gastrulation, convergent extension (CE) cell movements are regulated through the non-canonical Wnt signaling pathway.Wnt signaling results in downstream activation of Rho GTPases that in turn regulate actin cytoskeleton rearrangements essential for co-ordinated CE cell movement.Rho GTPases are bi-molecular switches that are inactive in their